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KMID : 0616120100410030190
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Korean Journal of Pharmacognosy
2010 Volume.41 No. 3 p.190 ~ p.195
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Neuroprotective Effects of the Extract of Zingiberis Rhizoma
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Jeong Gil-Saeng
Li Bin
Lee Dong-Sung
Choi Hyun-Gyu
Kim Youn-Chul
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Abstract
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Glutamate-induced oxidative injury contributes to neuronal degeneration in many central nervous system (CNS) diseases, such as Parkinson’s disease, Alzheimer’s disease, epilepsy and ischemia. Inducible heme oxygenase (HO)-1 acts against oxidants that are thought to play a role in the pathogenesis of these diseases. NNMBS098, a composition comprising the water insoluble of the 70% EtOH extract of Zingiberis Rhizoma, showed the potent neuroprotective effects on glutamateinduced neurotoxicity by induced the expression of heme oxygenase (HO)-1 and increased HO activity in the mouse hippocampal HT22 cells. Furthermore, NNMBS098 caused the nuclear accumulation of nuclear factor E2-related factor 2 (Nrf2) in mouse hippocampal HT22 cells. In addition, we found that treatment with c-Jun N-terminal kinase (JNK) inhibitor (SP600125) reduced NNMBS098-induced HO-1 expression and NNMBS098 also increased JNK phosphorylation. Therefore, these results suggest that NNMBS098 increases cellular resistance to glutamate-induced oxidative injury in mouse hippocampal HT22 cells, presumably through JNK pathway-Nrf2-dependent HO-1 expression.
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KEYWORD
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Glutamate, HT22, Zingiberis Rhizoma, Heme Oxygenase-1, Neuroprotective effect
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